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The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults
Cardiovascular Therapeutics ( IF 3.1 ) Pub Date : 2021-10-26 , DOI: 10.1155/2021/4626062
Xianpeng Xu 1 , Jinke Huang 2 , Simin Wu 2 , Qingjie Ji 1 , Xuguang Guo 3 , Yong Huang 4, 5
Affiliation  

Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.

中文翻译:

中老年人血尿酸水平与高血压的关系

背景。关于血清尿酸(sUA)水平和高血压(HTN)的研究存在争议。为了调查 sUA 水平与中老年人 HTN 事件之间的关系,我们进行了这项研究。方法。纳入了来自全国健康和营养检查调查 (NHANES) 的 6399 名年龄≥40 岁的参与者。进行加权多元逻辑回归分析以评估sUA水平与HTN事件之间的关系,使用拟合的平滑曲线探索潜在的非线性关系。如果观察到非线性,则通过递归算法进一步计算拐点。结果. 发现 sUA 水平与 HTN 事件之间存在正相关关系。但是,它可能在不同的种族群体中有所不同,也可能在男性和女性之间有所不同。此外,男性(转折点:sUA 4.1 mg/dL)和白人(转折点:sUA 7.9 mg/dL)的 sUA 水平与 HTN 事件之间的关联呈 U 形曲线。结论。结果显示,中老年人的 sUA 水平与 HTN 的发生率呈正相关。然而,它在男性和白人中遵循 U 形曲线。
更新日期:2021-10-26
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