Purpose: 

To investigate the relationship of smoking, urbanicity, and diabetes to presumed ocular histoplasmosis syndrome (POHS) and associated choroidal neovascularization (CNV).

Methods: 

Medical records of 751 adult patients with POHS were reviewed, including 603 patients without CNV and 148 patients with CNV. Age-matched and gender-matched controls were randomly selected from the same practice for comparison. Statistical comparisons of smoking history, urbanicity, and diabetic history were performed using chi-square and conditional logistic regression analyses.

Results: 

Increased rates of current or former smoking, rural residence, and diabetes were found in patients with POHS compared with controls. POHS patients with CNV had increased rates of current or former smoking and rural residence as compared with controls.

Conclusion: 

A history of current or past smoking is associated with an increased risk of developing both POHS alone and POHS with CNV. We did not find a significant additional risk of smoking on the development of CNV in patients with POHS. Patients living in rural locations are more likely than those in urban locations to develop both POHS and POHS with CNV. Diabetics may be more likely to develop POHS than nondiabetics.

中文翻译：

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吸烟、农村居民和糖尿病是推测的眼组织胞浆菌病综合征的危险因素

目的： 

旨在调查吸烟、都市生活和糖尿病与推测的眼组织胞浆菌病综合征 (POHS) 和相关脉络膜新生血管 (CNV)的关系。

方法： 

回顾了 751 名成年 POHS 患者的病历，其中 603 名无 CNV 患者，148 名有 CNV 患者。从同一实践中随机选择年龄匹配和性别匹配的对照进行比较。使用卡方和条件逻辑回归分析对吸烟史、都市生活和糖尿病史进行统计比较。

结果： 

与对照组相比，POHS 患者当前或既往吸烟、农村居住和糖尿病的发生率有所增加。与对照组相比，患有 CNV 的 POHS 患者当前或曾经吸烟和居住在农村的比例有所增加。

结论： 

当前或既往吸烟史与单纯 POHS 和 POHS 合并 CNV 的风险增加相关。我们没有发现吸烟对 POHS 患者发生 CNV 具有显着的额外风险。居住在农村地区的患者比居住在城市地区的患者更有可能同时发生 POHS 和 POHS 合并 CNV。糖尿病患者比非糖尿病患者更容易患 POHS。