Corneal Sensation and Nerve Fiber Changes in Patients With Interstitial Cystitis,Cornea

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Corneal Sensation and Nerve Fiber Changes in Patients With Interstitial Cystitis
Cornea ( IF 2.8 ) Pub Date : 2022-06-01 , DOI: 10.1097/ico.0000000000002887
Veysel Aykut _{1,

2} , Ipek Cigdem Ucar _{1,

2} , Semra Akkaya Turhan ₃ , Taha Ucar _{4,

5} , Ebubekir Durmus _{1,

2} , Halit Oguz _{1,

2} , Fehim Esen _{1,

2} , Bulent Erol _{4,

5}

Affiliation

Purpose:

Central sensitization syndromes are associated with ocular surface discomfort and certain changes in corneal sensation. The aim of this study was to evaluate corneal changes in patients with interstitial cystitis (IC).

Methods:

Thirty patients with IC and 32 healthy control subjects were included in this study. All patients had a detailed ophthalmological examination including measurement of corneal sensation with Cochet–Bonnet esthesiometer, tear breakup time, Schirmer I test, and Ocular Surface Disease Index questionnaire. After these examinations, corneal subbasal nerve plexus of the patients was evaluated with in vivo corneal confocal microscopy (IVCM) and the images were analyzed using fully automated software (ACC Metrics Corneal Nerve Fiber Analyzer V.2).

Results:

There was no significant difference between the groups regarding age and gender distribution. Corneal sensation was significantly higher in patients with IC (P = 0.03), whereas tear breakup time, Schirmer I test, and Ocular Surface Disease Index scores were similar between the patients and controls. IVCM demonstrated nerve fiber loss in patients with IC. Corneal nerve fiber density, corneal nerve branch density, and corneal nerve fiber length were significantly reduced in patients with IC compared with healthy controls (P < 0.001, P = 0.04, and P < 0.001, respectively).

Conclusions:

Patients with IC had increased corneal sensation and decreased nerve fiber density in IVCM analysis. Corneal nerve fiber loss might decrease the induction threshold of the remaining fibers to induce peripheral sensitization, which may also trigger central sensitization in long term.

中文翻译：

间质性膀胱炎患者角膜感觉和神经纤维的变化

目的：

中枢敏化综合征与眼表不适和角膜感觉的某些变化有关。本研究的目的是评估间质性膀胱炎（IC）患者的角膜变化。

方法：

本研究包括 30 名 IC 患者和 32 名健康对照受试者。所有患者均接受了详细的眼科检查，包括用 Cochet-Bonnet 感觉计测量角膜感觉、泪膜破裂时间、Schirmer I 测试和眼表疾病指数问卷。这些检查后，使用体内角膜共聚焦显微镜（IVCM）评估患者的角膜基底神经丛，并使用全自动软件（ACC Metrics Corneal Nerve Fiber Analyzer V.2）分析图像。

结果：

各组之间的年龄和性别分布没有显着差异。IC 患者的角膜感觉明显较高（P = 0.03），而患者和对照组之间的泪液破裂时间、Schirmer I 测试和眼表疾病指数评分相似。IVCM 证实 IC 患者神经纤维缺失。与健康对照相比，IC患者的角膜神经纤维密度、角膜神经分支密度和角膜神经纤维长度均显着降低（分别为P < 0.001、P = 0.04和P < 0.001）。