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Shear stress–induced cellular senescence blunts liver regeneration through Notch–sirtuin 1–P21/P16 axis
Hepatology ( IF 13.5 ) Pub Date : 2021-10-23 , DOI: 10.1002/hep.32209
Juan-Li Duan 1 , Bai Ruan 1, 2, 3 , Ping Song 1 , Zhi-Qiang Fang 1 , Zhen-Sheng Yue 1, 4 , Jing-Jing Liu 1 , Guo-Rui Dou 4 , Hua Han 1, 2 , Lin Wang 1
Affiliation  

The mechanisms involved in liver regeneration after partial hepatectomy (pHx) are complicated. Cellular senescence, once linked to aging, plays a pivotal role in wound repair. However, the regulatory effects of cellular senescence on liver regeneration have not been fully elucidated.

中文翻译:

剪切应力诱导的细胞衰老通过 Notch-sirtuin 1-P21/P16 轴抑制肝脏再生

部分肝切除术(pHx)后肝脏再生的机制很复杂。细胞衰老曾经与衰老有关,在伤口修复中起着关键作用。然而,细胞衰老对肝再生的调节作用尚未完全阐明。
更新日期:2021-10-23
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