Although we agree with Dutta et al. (1) that our conclusion could be more comprehensive, we disagree that our study design and interpretations are biased (2). Neutrophils in asthma are linked to worsening symptoms, but their role as key determinant cells remains obscure in the pathogenesis (3). Reducing neutrophilic inflammation in asthma does not yield any meaningful outcome in clinical trials and animal models (4, 5). Studies of multiple species have demonstrated that a healthy lung maintains a large pool of neutrophils that predominantly marginate within lung tissue (6). This is critical for rapid host defense. Importantly, dexamethasone (DEX) is known to promote the survival of neutrophils (7). Our endpoint …

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回复 Dutta 等人：在组织微环境的背景下理解 scRNA-seq 数据需要临床相关性 [免疫学和炎症]

尽管我们同意 Dutta 等人的观点。( 1 ) 我们的结论可能更全面，但我们不同意我们的研究设计和解释存在偏见 ( 2 )。哮喘中的中性粒细胞与症状恶化有关，但它们作为关键决定细胞的作用在发病机制中仍不清楚 ( 3 )。在临床试验和动物模型中，减少哮喘中的中性粒细胞炎症不会产生任何有意义的结果 ( 4 , 5 )。对多个物种的研究表明，健康的肺会维持大量嗜中性粒细胞，这些嗜中性粒细胞主要位于肺组织内（6）。这对于快速主机防御至关重要。重要的是，已知地塞米松 (DEX) 可促进中性粒细胞的存活 ( 7 )。我们的终点……