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The value of studying rare genetic variants and other emerging themes in neurogenetics
Brain ( IF 14.5 ) Pub Date : 2021-10-21 , DOI: 10.1093/brain/awab323
Bryan J Traynor 1 , Rebecca F Gottesman 1
Affiliation  

Although white matter hyperintensities on fluid-attenuated inversion recovery (FLAIR) brain MRI are frequent incidental findings without any apparent clinical abnormality, they are widely viewed as an imaging marker of cerebral small vessel disease1 and indicate future risk of stroke and other adverse outcomes.2 Furthermore, understanding the origin and risk factors for this common entity is crucial because of its contribution to cognitive impairment and dementia.3 Reducing its occurrence will likely help decrease the dementia burden in the community and lower healthcare expenditures.

中文翻译:

研究神经遗传学中罕见遗传变异和其他新兴主题的价值

尽管液体衰减反转恢复 (FLAIR) 脑 MRI 的白质高信号是常见的偶然发现,没有任何明显的临床异常,但它们被广泛视为脑小血管疾病的成像标志1,并表明未来发生中风和其他不良后果的风险。2此外,了解这种常见实体的起源和风险因素至关重要,因为它会导致认知障碍和痴呆症。3减少其发生可能有助于减轻社区的痴呆负担并降低医疗保健支出。
更新日期:2021-10-25
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