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The current state of SubtiWiki, the database for the model organism Bacillus subtilis
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2021-10-01 , DOI: 10.1093/nar/gkab943
Tiago Pedreira 1 , Christoph Elfmann 1 , Jörg Stülke 1
Affiliation  

Bacillus subtilis is a Gram-positive model bacterium with extensive documented annotation. However, with the rise of high-throughput techniques, the amount of complex data being generated every year has been increasing at a fast pace. Thus, having platforms ready to integrate and give a representation to these data becomes a priority. To address it, SubtiWiki (http://subtiwiki.uni-goettingen.de/) was created in 2008 and has been growing in data and viewership ever since. With millions of requests every year, it is the most visited B. subtilis database, providing scientists all over the world with curated information about its genes and proteins, as well as intricate protein–protein interactions, regulatory elements, expression data and metabolic pathways. However, there is still a large portion of annotation to be unveiled for some biological elements. Thus, to facilitate the development of new hypotheses for research, we have added a Homology section covering potential protein homologs in other organisms. Here, we present the recent developments of SubtiWiki and give a guided tour of our database and the current state of the data for this organism.

中文翻译:

SubtiWiki 的现状,模式生物枯草芽孢杆菌的数据库

枯草芽孢杆菌是一种革兰氏阳性模型细菌,具有广泛的记录注释。然而,随着高通量技术的兴起,每年生成的复杂数据量一直在快速增长。因此,让平台准备好集成并为这些数据提供表示成​​为当务之急。为了解决这个问题,SubtiWiki (http://subtiwiki.uni-goettingen.de/) 创建于 2008 年,从那时起数据和收视率一直在增长。每年有数百万次请求,它是访问量最大的枯草芽孢杆菌数据库,为世界各地的科学家提供有关其基因和蛋白质的精选信息,以及复杂的蛋白质-蛋白质相互作用、调控元件、表达数据和代谢途径。然而,对于某些生物元素,仍有很大一部分注释有待揭示。因此,为了促进新的研究假设的发展,我们增加了一个同源部分,涵盖了其他生物体中潜在的蛋白质同源物。在这里,我们介绍了 SubtiWiki 的最新发展,并介绍了我们的数据库和该生物体数据的当前状态。
更新日期:2021-10-01
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