Various perivascular drug delivery techniques have been demonstrated for localized post-treatment of intimal hyperplasia: a vascular inflammatory response caused by endothelial damages. Although most perivascular devices have focused on controlling the delivery duration of anti-proliferation drug, the confined and unidirectional delivery of the drug to the target tissue has become increasingly important. In addition, careful attention should also be paid to the luminal stability and the adequate exchange of vascular protein or cell between the blood vessel and extravascular tissue to avoid any side effect from the long-term application of any perivascular device. Here, a highly flexible and porous silk fibroin microneedle wrap (Silk MN wrap) is proposed to directly inject antiproliferative drug to the anastomosis sites while ensuring sufficient vascular exchanges. Drug-embedded silk MNs were transfer-molded on a highly flexible and porous silk wrap. The enhanced cell compatibility, molecular permeability, and flexibility of silk MN wrap guaranteed the structural integrity of blood vessels. Silk wrap successfully supported the silk MNs and induced multiple MN penetration to the target tissue. Over 28 days, silk MN wrap significantly inhibited intimal hyperplasia with a 62.1% reduction in neointimal formation.

各种血管周围药物递送技术已被证明可用于内膜增生的局部后处理：由内皮损伤引起的血管炎症反应。尽管大多数血管周围装置都专注于控制抗增殖药物的输送时间，但药物向靶组织的受限和单向输送变得越来越重要。此外，还应注意管腔稳定性和血管与血管外组织之间血管蛋白或细胞的充分交换，以免长期使用任何血管周围装置产生副作用。这里，提出了一种高度灵活且多孔的丝素蛋白微针包裹物（Silk MN 包裹物），可在确保足够的血管交换的同时将抗增殖药物直接注射到吻合部位。药物嵌入的丝绸 MN 被转移成型在高度灵活和多孔的丝绸包装上。蚕丝 MN 包裹增强的细胞相容性、分子渗透性和柔韧性保证了血管的结构完整性。丝绸包裹成功地支持了丝绸 MNs 并诱导了多个 MN 渗透到目标组织。超过 28 天，丝质 MN 包裹显着抑制内膜增生，新内膜形成减少了 62.1%。丝质 MN 包裹物的柔韧性和柔韧性保证了血管的结构完整性。丝绸包裹成功地支持了丝绸 MNs 并诱导了多个 MN 渗透到目标组织。超过 28 天，丝质 MN 包裹显着抑制内膜增生，新内膜形成减少了 62.1%。丝质 MN 包裹物的柔韧性和柔韧性保证了血管的结构完整性。丝绸包裹成功地支持了丝绸 MNs 并诱导了多个 MN 渗透到目标组织。超过 28 天，丝质 MN 包裹显着抑制内膜增生，新内膜形成减少了 62.1%。