Up to 40% of patients with inflammatory bowel disease present with psychosocial disturbances. We previously identified a gut vascular barrier that controls the dissemination of bacteria from the intestine to the liver. Here, we describe a vascular barrier in the brain choroid plexus (PVB) that is modulated in response to intestinal inflammation through bacteria-derived lipopolysaccharide. The inflammatory response induces PVB closure after gut vascular barrier opening by the up-regulation of the wingless-type, catenin-beta 1 (Wnt/β-catenin) signaling pathway, rendering it inaccessible to large molecules. In a model of genetically driven closure of choroid plexus endothelial cells, we observed a deficit in short-term memory and anxiety-like behavior, suggesting that PVB closure may correlate with mental deficits. Inflammatory bowel disease–related mental symptoms may thus be the consequence of a deregulated gut–brain vascular axis.

中文翻译：

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肠道炎症期间脉络丛血管屏障闭合的鉴定

多达 40% 的炎症性肠病患者存在社会心理障碍。我们之前发现了一种肠道血管屏障，它控制细菌从肠道到肝脏的传播。在这里，我们描述了脑脉络丛 (PVB) 中的血管屏障，该屏障通过细菌衍生的脂多糖响应肠道炎症而受到调节。炎症反应通过上调无翼型连环蛋白-β1（Wnt/β-连环蛋白）信号通路，在肠道血管屏障打开后诱导 PVB 闭合，使其无法被大分子进入。在基因驱动的脉络丛内皮细胞闭合模型中，我们观察到短期记忆缺陷和焦虑样行为，这表明 PVB 闭合可能与精神缺陷相关。