The development of nanoparticles incorporating Gd³⁺ has attracted interest in the field of contrasting nanomedicine for magnetic resonance (MR) and computed tomography (CT). In order to achieve an effective contrasting performance, the amount and stability of Gd incorporated as well as particle-size control of the nanoparticles should be considered simultaneously. In the current study, Gd-diethylenetriaminepentaacetate(Gd-DTPA) was incorporated into layered double hydroxide (LDH) to meet the physicochemical properties required for MR-CT dual contrasting nanomedicine. Strategically, the particle size and nanometer incorporation of Gd-DTPA into LDH (GL-R hybrid) were controlled homogeneously using the reverse micelle method. X-ray diffraction showed that the hybrid obtained possessed a hydrotalcite phase. Dynamic light scattering and electron microscopic analyses showed that the hybrid had a controlled size of <200 nm with significant homogeneity. Fast Fourier-transform of transmission electron microscopy confirmed that the platelets of the GL-R hybrids were oriented randomly to form inter-particle space, enabling the Gd-DTPA moiety to be encapsulated stably. The encapsulation efficiency of Gd-DTPA was 20.8%, which was sufficiently high compared with other Gd-DTPA-incorporatedLDH. According to X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy, Gd-DTPA incorporated in the hybrid preserved its structure intact. Its potential as a dual modal contrast agent was demonstrated by measuring the concentration-dependent Hounsfield unit and magnetic resonance relaxivity, which were determined to be 230 at 2 mg/mL and 5.8 in the range ~0.2–1 mM-Gd, respectively.

Gd ³⁺纳米粒子的开发已经引起了对用于磁共振 (MR) 和计算机断层扫描 (CT) 的对比纳米医学领域的兴趣。为了实现有效的对比性能，应同时考虑掺入的 Gd 的数量和稳定性以及纳米颗粒的粒径控制。在目前的研究中，将 Gd-二亚乙基三胺五乙酸盐 (Gd-DTPA) 掺入层状双氢氧化物 (LDH) 中，以满足 MR-CT 双对比纳米医学所需的理化特性。从战略上讲，使用反胶束方法均匀控制 Gd-DTPA 与 LDH（GL-R 杂化）的粒径和纳米结合。X 射线衍射表明获得的杂化物具有水滑石相。动态光散射和电子显微镜分析表明，杂化物的尺寸可控，<200 nm，具有显着的均匀性。透射电子显微镜的快速傅立叶变换证实 GL-R 杂化物的片晶随机取向以形成颗粒间空间，使 Gd-DTPA 部分能够被稳定地包封。Gd-DTPA 的包封率为 20.8%，与其他掺入 Gd-DTPA 的 LDH 相比已足够高。根据 X 射线光电子能谱和傅里叶变换红外光谱，掺入混合体中的 Gd-DTPA 保持其结构完整。通过测量浓度依赖的 Hounsfield 单位和磁共振弛豫率证明了其作为双模态造影剂的潜力，在 2 mg/mL 和 5 时确定为 230。