当前位置: X-MOL 学术Rheumatology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Histopathology, salivary flow and ultrasonography of the parotid gland: three complementary measurements in primary Sjögren’s syndrome
Rheumatology ( IF 5.5 ) Pub Date : 2021-10-19 , DOI: 10.1093/rheumatology/keab781
Esther Mossel 1 , Martha S van Ginkel 1 , Erlin A Haacke 1, 2 , Suzanne Arends 1 , Silvia C Liefers 1 , Konstantina Delli 3 , Jolien F van Nimwegen 1 , Alja J Stel 1 , Fred K L Spijkervet 3 , Arjan Vissink 3 , Bert van der Vegt 2 , Frans G M Kroese 1 , Hendrika Bootsma 1
Affiliation  

Objective The involvement of salivary glands in primary SS (pSS) can be assessed in different ways: histopathology, salivary flow and ultrasonography. To understand the relative value of these different approaches, it is crucial to understand the relationship between them. As we routinely perform these three modalities in the parotid gland for disease evaluation, our aim was to investigate the construct validity between these modalities in one and the same gland. Methods Consecutive sicca patients underwent a multidisciplinary diagnostic workup including parotid gland biopsy, collection of parotid gland–specific saliva and parotid gland ultrasonography. Patients who were classified as pSS according to the ACR-EULAR criteria were included. Construct validity was assessed using Spearman’s correlation coefficients. Results The 41 included pSS patients completed a full workup within a mean time interval of 2.6 months. Correlations between histopathological features and stimulated parotid salivary flow were fair (ρ = −0.123 for focus score and ρ = −0.259 for percentage of CD45+ infiltrate). Likewise, poor correlations were observed between stimulated parotid salivary flow and parotid ultrasonography (ρ = −0.196). Moderate to good associations were found between the histopathological items focus score and the percentage of CD45+ infiltrate, with parotid US scores (total US score: ρ = 0.510 and ρ = 0.560; highest for homogeneity: ρ = 0.574 and ρ = 0.633). Conclusion Although pSS-associated ultrasonographic findings did correlate with histopathological features, the three modalities that evaluate salivary gland involvement assess different (or at best partly related) constructs. Therefore histopathology, salivary flow and ultrasonography are complementary measurements and cannot directly replace each other in the workup of pSS.

中文翻译:

腮腺的组织病理学、唾液流量和超声检查:原发性干燥综合征的三种互补测量

目的 唾液腺在原发性 SS (pSS) 中的受累可以通过不同的方式进行评估:组织病理学、唾液流量和超声检查。要了解这些不同方法的相对价值,了解它们之间的关系至关重要。由于我们经常在腮腺中执行这三种方式进行疾病评估,我们的目的是研究这些方式在同一个腺体中的结构有效性。方法 连续性干燥患者接受了多学科诊断检查,包括腮腺活检、腮腺特异性唾液采集和腮腺超声检查。纳入根据 ACR-EULAR 标准分类为 pSS 的患者。使用 Spearman 相关系数评估结构效度。结果 41 名 pSS 患者在平均 2.6 个月的时间间隔内完成了全面检查。组织病理学特征和受刺激的腮腺唾液流之间的相关性是公平的(焦点评分 ρ = -0.123,CD45+ 浸润百分比 ρ = -0.259)。同样,在受刺激的腮腺唾液流和腮腺超声检查之间观察到较差的相关性(ρ = -0.196)。在组织病理学项目焦点评分和 CD45+ 浸润百分比之间发现了中度至良好的关联,腮腺超声评分(美国总评分:ρ = 0.510 和 ρ = 0.560;同质性最高:ρ = 0.574 和 ρ = 0.633)。结论 虽然 pSS 相关的超声检查结果确实与组织病理学特征相关,但 评估唾液腺受累的三种方式评估不同(或至多部分相关)的结构。因此,组织病理学、唾液流量和超声检查是互补的测量方法,在 pSS 的检查中不能直接相互替代。
更新日期:2021-10-19
down
wechat
bug