Abstract

 

Abstract OBJECTIVES

Pericardial effusion is a common complication after cardiac surgery, both isolated and in post-pericardiotomy syndrome (PPS), a condition in which pleuropericardial damage triggers both a local and a systemic inflammatory/immune response. The goal of this review was to present a complete picture of PPS and pericardial complications after cardiac surgery, highlighting available evidence and gaps in knowledge.

METHODS

A literature review was performed that included relevant prospective and retrospective studies on the subject.

RESULTS

PPS occurs frequently and is associated with elevated morbidity and significantly increased hospital stays and costs. Nevertheless, PPS is often underestimated in clinical practice, and knowledge of its pathogenesis and epidemiology is limited. Several anti-inflammatory drugs have been investigated for treatment but with conflicting evidence. Colchicine demonstrated encouraging results for prevention.

CONCLUSIONS

Wider adoption of standardized diagnostic criteria to correctly define PPS and start early treatment is needed. Larger studies are necessary to better identify high-risk patients who might benefit from preventive strategies.

中文翻译：

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心包切开术后综合征：对被忽视的术后问题的见解

摘要

 

抽象目标

心包积液是心脏手术后的常见并发症，无论是孤立的还是心包切开术后综合征 (PPS)，胸膜心包损伤都会引发局部和全身炎症/免疫反应。本综述的目的是呈现心脏手术后 PPS 和心包并发症的全貌，突出现有证据和知识空白。

方法

进行了文献回顾，其中包括有关该主题的相关前瞻性和回顾性研究。

结果

PPS 经常发生，并与发病率升高和住院时间和费用显着增加有关。然而，PPS在临床实践中经常被低估，对其发病机制和流行病学的了解有限。已经研究了几种抗炎药用于治疗，但证据相互矛盾。秋水仙碱的预防效果令人鼓舞。

结论

需要更广泛地采用标准化诊断标准来正确定义 PPS 并开始早期治疗。需要更大规模的研究来更好地识别可能从预防策略中受益的高危患者。