Angiosarcoma is a widely known neoplasm with one of the poorest prognoses; however, such cases are rarely observed by the ophthalmologists in clinical practice. The tumor commonly develops on the face and scalp and may cause eyelid swelling. We present two such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy revealed a poorly circumscribed tumor infiltrated throughout the dermis and fat tissue, exhibiting both angiomatous and solid patterns. Immunohistochemistry showed CD31 (-) and D2-40/podoplanin(+), suggesting angiosarcoma. The patient had multiple lung metastases and died 14 months later. Case 2 was a 77-year-old man who presented with swelling of the left eyelid and erythema on the left temporal skin developed ulcerated nodules. Biopsy showed proliferated tumor cells in a sheet form, extensively throughout the dermis. Angiosarcoma was preferred based on immunohistochemistry: CD31(+), CD34(+), D2-40(-). The patient was treated with electron beam therapy and chemotherapy, and died after 13 months. It would be difficult for an ophthalmologist to suspect such a rare neoplasm only from swelling of the eyelids. However, angiosarcoma should be considered if the swelling spreads steadily from a head rash with a nodule or ulcer nearby.


中文翻译：

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血管肉瘤伴单侧眼睑持续肿胀2例

血管肉瘤是一种广为人知的肿瘤，预后最差。然而，眼科医生在临床实践中很少观察到此类病例。肿瘤通常发生在面部和头皮上，并可能导致眼睑肿胀。我们提出两个这样的案例。病例 1 是一名 82 岁女性，她出现右眼睑肿胀并延伸至前额上方。活检显示边界不清的肿瘤浸润整个真皮和脂肪组织，呈现血管瘤样和实性模式。免疫组化显示 CD31 (-) 和 D2-40/podoplanin(+)，提示血管肉瘤。患者有多处肺转移，14个月后死亡。病例 2 是一名 77 岁男性，患者出现左眼睑肿胀，左侧颞部皮肤出现红斑，出现结节溃疡。活检显示增殖的肿瘤细胞呈片状，广泛遍及整个真皮。根据免疫组织化学，首选血管肉瘤：CD31(+)、CD34(+)、D2-40(-)。患者接受电子束疗法和化学疗法治疗，13个月后死亡。眼科医生很难仅从眼睑肿胀来怀疑这种罕见的肿瘤。但是，如果肿胀从附近有结节或溃疡的头部皮疹稳定扩散，则应考虑血管肉瘤。眼科医生很难仅从眼睑肿胀来怀疑这种罕见的肿瘤。但是，如果肿胀从附近有结节或溃疡的头部皮疹稳定扩散，则应考虑血管肉瘤。眼科医生很难仅从眼睑肿胀来怀疑这种罕见的肿瘤。但是，如果肿胀从附近有结节或溃疡的头部皮疹稳定扩散，则应考虑血管肉瘤。