Intracranial hypertension is a serious threat to the health of neurosurgical patients. At present, there is a lack of a safe and effective technology to monitor intracranial pressure (ICP) accurately and nondestructively. In this paper, based on near infrared technology, the continuous nondestructive monitoring of ICP change caused by brain edema was studied. The rat brain edema models were constructed by lipopolysaccharide. The ICP monitor and the self-made near infrared tissue parameter measuring instrument were used to monitor the invasive intracranial pressure and the reduced scattering coefficient of brain tissue during the brain edema development. The results showed that there was a negative correlation between the reduced scattering coefficient (690nm and 834nm) and ICP, and then the mathematical model was established. The experimental results promoted the development of nondestructive ICP monitoring based on near infrared technology.

中文翻译：

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脑水肿模型降低散射系数与颅内压关系的研究

颅内高压对神经外科患者的健康构成严重威胁。目前，缺乏一种安全有效的技术来准确、无损地监测颅内压（ICP）。本文基于近红外技术，研究了脑水肿引起的ICP变化的连续无损监测。采用脂多糖构建大鼠脑水肿模型。采用ICP监测仪和自制近红外组织参数测量仪监测脑水肿发展过程中的有创颅内压和脑组织降低的散射系数。结果表明，降低的散射系数（690纳米和 834nm）和ICP，然后建立数学模型。实验结果促进了基于近红外技术的无损ICP监测的发展。