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Generalizability of the Results and Concerns About Leakage Rates of the ICAN Trial
JAMA Surgery ( IF 16.9 ) Pub Date : 2022-02-01 , DOI: 10.1001/jamasurg.2021.5263
Wobbe O de Steur 1 , Merlijn Hutteman 1, 2 , Henk H Hartgrink 1
Affiliation  

To the Editor With interest we have read the randomized clinical trial by van Workum et al. In their article, the authors show a reduction in anastomotic leakage rate from 31.7% to 12.3% with the introduction of an intrathoracic anastomosis. They conclude that “intrathoracic, as opposed to cervical, anastomosis resulted in better outcome for patients treated with transthoracic MIE [minimally invasive esophagectomy] for midesophageal to distal esophageal or gastroesophageal junction cancer.” Although this study is well performed and the authors have to be congratulated, we cannot fully concur with the conclusion and future recommendations in their article.

中文翻译:

结果的普遍性和对 ICAN 试验泄漏率的担忧

致编辑我们感兴趣地阅读了 van Workum 等人的随机临床试验。在他们的文章中,作者表明,随着胸内吻合术的引入,吻合口漏率从 31.7% 降低到 12.3%。他们得出的结论是:“与颈椎相比,胸腔内吻合术对接受经胸 MIE [微创食管切除术] 治疗食管中段至食管远端或胃食管交界处癌的患者有更好的结果。” 尽管这项研究表现良好并且必须祝贺作者,但我们不能完全同意他们文章中的结论和未来建议。
更新日期:2022-02-10
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