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Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility
ACS Nano ( IF 17.1 ) Pub Date : 2021-10-20 , DOI: 10.1021/acsnano.1c07343
Shoupeng Cao 1 , Hanglong Wu 1 , Imke A B Pijpers 1 , Jingxin Shao 1 , Loai K E A Abdelmohsen 1 , David S Williams 2 , Jan C M van Hest 1
Affiliation  

Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well as phototherapeutics. An intriguing feature that has not been explored yet is their ability to adopt a range of asymmetric morphologies. Structural asymmetry allows nanoparticles to be exploited as active (motile) systems. Here, we present the design and preparation of AIE fluorophore integrated (AIEgenic) cucurbit-shaped polymersome nanomotors with enzyme-powered motility. The cucurbit scaffold was constructed via morphology engineering of biodegradable fluorescent AIE-polymersomes, followed by functionalization with enzymatic machinery via a layer-by-layer (LBL) self-assembly process. Because of the enzyme-mediated decomposition of chemical fuel on the cucurbit-like nanomotor surface, enhanced directed motion was attained, when compared with the spherical counterparts. These cucurbit-shaped biodegradable AIE-nanomotors provide a promising platform for the development of active delivery systems with potential for biomedical applications.

中文翻译:

具有聚集诱导发射特性的葫芦状聚合物囊泡显示出酶介导的运动性

包含聚集诱导发射 (AIE) 部分的聚合物囊泡是具有吸引力的固有荧光纳米粒子,具有用于细胞/组织成像和跟踪以及光疗的生物医学应用潜力。一个尚未探索的有趣特征是它们采用一系列不对称形态的能力。结构不对称性允许纳米粒子被用作活性(运动)系统。在这里,我们介绍了具有酶驱动动力的 AIE 荧光团集成 (AIEgenic) 葫芦形聚合物纳米马达的设计和制备。葫芦支架是通过可生物降解的荧光 AIE 聚合物囊泡的形态工程构建的,然后通过逐层 (LBL) 自组装过程用酶机械进行功能化。由于酶介导的化学燃料在葫芦状纳米马达表面的分解,与球形对应物相比,获得了增强的定向运动。这些葫芦形可生物降解的 AIE 纳米马达为开发具有生物医学应用潜力的主动输送系统提供了一个有前途的平台。
更新日期:2021-11-23
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