The Lancet Global Health ( IF 34.3 ) Pub Date : 2021-10-19 , DOI: 10.1016/s2214-109x(21)00350-8 Shanti Narayanasamy 1 , Vu Quoc Dat 2 , Nguyen Tat Thanh 3 , Vo Trieu Ly 4 , Jasper Fuk-Woo Chan 5 , Kwok-Yung Yuen 5 , Chuanyi Ning 6 , Hao Liang 6 , Linghua Li 7 , Anuradha Chowdhary 8 , Sirida Youngchim 9 , Khuanchai Supparatpinyo 10 , Ne Myo Aung 11 , Josh Hanson 12 , Alex Andrianopoulos 13 , John Dougherty 1 , Nelesh P Govender 14 , David W Denning 15 , Tom Chiller 16 , Guy Thwaites 17 , H Rogier van Doorn 17 , John Perfect 1 , Thuy Le 18
Talaromycosis (penicilliosis) is an invasive mycosis that is endemic in tropical and subtropical Asia. Talaromycosis primarily affects individuals with advanced HIV disease and other immunosuppressive conditions, and the disease disproportionally affects people in low-income and middle-income countries, particularly agricultural workers in rural areas during their most economically productive years. Approximately 17 300 talaromycosis cases and 4900 associated deaths occur annually. Talaromycosis is highly associated with the tropical monsoon season, when flooding and cyclones can exacerbate the poverty-inducing potential of the disease. Talaromycosis can present as localised or disseminated disease, the latter causing cutaneous lesions that are disfiguring and stigmatising. Despite up to a third of diagnosed cases resulting in death, talaromycosis has received little attention and investment from regional and global funders, policy makers, researchers, and industry. Diagnostic and treatment modalities remain extremely insufficient, however control of talaromycosis is feasible with known public health strategies. This Viewpoint is a global call for talaromycosis to be recognised as a neglected tropical disease to alleviate its impact on susceptible populations.
中文翻译:
全球呼吁将踝关节真菌病视为一种被忽视的热带病
踝部真菌病(青霉病)是一种侵袭性真菌病,在亚洲热带和亚热带地区流行。Talaromycosis 主要影响患有晚期 HIV 疾病和其他免疫抑制疾病的个体,并且这种疾病不成比例地影响低收入和中等收入国家的人们,特别是在经济生产力最高的农村地区的农业工人。每年大约发生 17 300 例踝关节真菌病病例和 4900 例相关死亡。踝部真菌病与热带季风季节密切相关,届时洪水和飓风会加剧该病引发贫困的可能性。Talaromycosis 可以表现为局部或播散性疾病,后者会导致毁容和污名化的皮肤损伤。尽管高达三分之一的确诊病例导致死亡,talaromycosis 很少受到区域和全球资助者、政策制定者、研究人员和行业的关注和投资。诊断和治疗方式仍然非常不足,但是通过已知的公共卫生策略控制踝关节菌病是可行的。该观点呼吁全球将踝关节真菌病视为一种被忽视的热带病,以减轻其对易感人群的影响。