Telomere length is considered as a clock mirroring aging and is influenced by oxidative stress and inflammation. Both conditions are highly prevalent in patients with chronic kidney disease and other degenerative disorders, such as cardiovascular disease. However, it is discussed controversially whether short telomeres are causally associated with chronic kidney disease or whether chronic kidney disease is contributing to an attrition of telomere length. Park et al., in this issue of Kidney International, use an extended 2-sample Mendelian randomization analysis with large data sets to shed new light on this research question.

中文翻译：

---

端粒长度和慢性肾病：原因还是结果？

端粒长度被认为是反映衰老的时钟，并受氧化应激和炎症的影响。这两种情况在患有慢性肾病和其他退行性疾病（如心血管疾病）的患者中非常普遍。然而，短端粒是否与慢性肾病有因果关系，或者慢性肾病是否会导致端粒长度的减少，存在争议。帕克等人。，在本期Kidney International 中，使用大数据集的扩展 2 样本孟德尔随机化分析来阐明这一研究问题。