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Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects
Bioengineering & Translational Medicine ( IF 7.4 ) Pub Date : 2021-10-18 , DOI: 10.1002/btm2.10262
Duraipandy Natarajan 1 , Zhitong Ye 1 , Liping Wang 1 , Linhu Ge 1 , Janak Lal Pathak 1
Affiliation  

Bone grafts or prosthetic implant designing for clinical application is challenging due to the complexity of integrated physiological processes. The revolutionary advances of nanotechnology in the biomaterial field expedite and endorse the current unresolved complexity in functional bone graft and implant design. Rare earth (RE) materials are emerging biomaterials in tissue engineering due to their unique biocompatibility, fluorescence upconversion, antimicrobial, antioxidants, and anti-inflammatory properties. Researchers have developed various RE smart nano-biomaterials for bone tissue engineering and implantology applications in the past two decades. Furthermore, researchers have explored the molecular mechanisms of RE material-mediated tissue regeneration. Recent advances in biomedical applications of micro or nano-scale RE materials have provided a foundation for developing novel, cost-effective bone tissue engineering strategies. This review attempted to provide an overview of RE nanomaterials' technological innovations in bone tissue engineering and implantology and summarized the osteogenic, angiogenic, immunomodulatory, antioxidant, in vivo bone tissue imaging, and antimicrobial properties of various RE nanomaterials, as well as the molecular mechanisms involved in these biological events. Further, we extend to discuss the challenges and prospects of RE smart nano-biomaterials in the field of bone tissue engineering and implantology.

中文翻译:

用于骨组织工程和种植学的稀土智能纳米材料:进展、挑战和前景

由于综合生理过程的复杂性,临床应用的骨移植或假体植入物设计具有挑战性。纳米技术在生物材料领域的革命性进步加速并支持了目前功能性骨移植和植入物设计中尚未解决的复杂性。稀土(RE)材料因其独特的生物相容性、荧光上转换、抗菌、抗氧化和抗炎特性而成为组织工程中的新兴生物材料。在过去的二十年里,研究人员开发了各种用于骨组织工程和种植学应用的稀土智能纳米生物材料。此外,研究人员还探索了稀土材料介导的组织再生的分子机制。微米级或纳米级稀土材料生物医学应用的最新进展为开发新型、具有成本效益的骨组织工程策略奠定了基础。本文试图概述稀土纳米材料在骨组织工程和种植学方面的技术创新,总结各种稀土纳米材料的成骨、血管生成、免疫调节、抗氧化、体内骨组织成像和抗菌特性及其分子机制。参与这些生物事件。此外,我们还进一步讨论了RE智能纳米生物材料在骨组织工程和种植领域的挑战和前景。
更新日期:2021-10-18
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