A new study reports that common mitochondrial DNA variants in specific haplogroups induce metabolic alterations that affect the onset of common age-related diseases. Unravelling the role of this subtle, long-lasting burden of mitochondrial DNA variants on kidney homeostasis could provide novel insights into the pathophysiology of chronic kidney disease.

中文翻译：

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线粒体 DNA 变异的微妙长期负担

一项新的研究报告说，特定单倍群中常见的线粒体 DNA 变异会诱导代谢改变，从而影响常见的与年龄相关的疾病的发作。揭示线粒体 DNA 变异这种微妙而持久的负担对肾脏稳态的作用，可以为慢性肾脏疾病的病理生理学提供新的见解。