The enantioselective benzylation of racemic isoprene monoxide is achieved through a two-step Pd-catalyzed substitution–decarboxylation strategy. A variety of electron-poor (hetero)arylacetates can be used as benzyl nucleophile surrogates to give products with acyclic quaternary stereocenters in 80–96 % ee.

中文翻译：

---

对映选择性叔亲电（杂）苄基化：Pd 催化的一氧化异戊二烯与芳基乙酸酯的取代**

外消旋一氧化异戊二烯的对映选择性苄基化是通过两步 Pd 催化的取代 - 脱羧策略实现的。各种缺电子（杂）芳基乙酸酯可用作苄基亲核试剂的替代物，以提供具有 80-96% ee 的无环四元立体中心的产品。