The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.

中文翻译：

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人类泌尿外泌体的遗传来源追踪[遗传学]

我们体液中纳米级细胞外囊泡的遗传起源仍不清楚。在这里，我们通过 RNA 测序对尿液外泌体进行了跟踪分析，发现尿液外泌体主要表达膀胱的组织特异性基因，并且与内皮细胞、基底细胞、单核细胞和树突状细胞具有密切的细胞遗传关系。追踪癌症的差异表达基因和相应的富集分析表明，尿液外泌体与免疫活动密切相关，表明它们可以作为癌症基因组诊断和精准医学中无创液体活检的可靠生物标志物。