Organosolv pretreatment can be considered as the core of the lignocellulosic biomass fractionation within the biorefinery concept. Organosolv facilitates the separation of the major fractions (cellulose, hemicelluloses, lignin), and their use as renewable feedstocks to produce bioenergy, biofuels, and added-value biomass derived chemicals. The efficient separation of these fractions affects the economic feasibility of the biorefinery complex. This review focuses on the simulation of the organosolv pretreatment and the optimization of (i) feedstock delignification, (ii) sugars production (mainly from hemicelluloses), (iii) enzymatic digestibility of the cellulose fraction and (iv) quality of lignin. Simulation is used for the technoeconomic optimization of the biorefinery complex. Simulation and optimization implement a holistic approach considering the efficient technological, economic, and environmental performance of the biorefinery operational units. Consequently, an optimized organosolv stage is the first step for a sustainable, economically viable biorefinery complex in the concept of industrial ecology and zero waste circular economy.

有机溶剂预处理可被视为生物精炼概念中木质纤维素生物质分馏的核心。Organosolv 促进了主要部分（纤维素、半纤维素、木质素）的分离，并将它们用作可再生原料来生产生物能源、生物燃料和具有附加值的生物质衍生化学品。这些馏分的有效分离会影响生物精炼厂的经济可行性。本综述重点关注有机溶剂预处理的模拟和 (i) 原料脱木素、(ii) 糖生产（主要来自半纤维素）、(iii) 纤维素部分的酶消化率和 (iv) 木质素质量的优化。模拟用于生物精炼综合体的技术经济优化。考虑到生物精炼操作单元的高效技术、经济和环境性能，模拟和优化实施了一种整体方法。因此，在工业生态和零废物循环经济的概念中，优化的有机溶剂阶段是可持续、经济可行的生物精炼综合体的第一步。