Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis,Hepatology

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Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis
Hepatology ( IF 13.5 ) Pub Date : 2021-10-18 , DOI: 10.1002/hep.32203
Kunpeng Hu _{1,

2} , Maria C Perez-Matos ₁ , Josepmaria Argemi _{3,

4} , Eduardo Vilar-Gomez ₅ , Irina Shalaurova ₆ , Esther Bullitt ₇ , Lee Landeen ₈ , Go Sugahara _{9,

10} , Huiyan Deng ₁ , Karan Mathur ₅ , Stephanie Tran ₁ , Huimei Cai ₁ , Hanchang He ₁ , Yusuf Yalcin ₁ , Joana Vieira Barbosa _{1,

11} , Meritxell Ventura-Cots ₃ , Katherine Marx ₁₂ , Aniket P Gad ₁₃ , Sebastian Niezen ₁ , Sofia Izunza Barba ₁ , Lay-Hong Ang ₁₃ , Yury V Popov ₁ , Zachary Fricker ₁ , Michelle Lai ₁ , Michael Curry ₁ , Nezam Afdhal ₁ , Gyongyi Szabo ₁ , Kenneth J Mukamal ₁₄ , Arun J Sanyal ₁₅ , James D Otvos ₆ , Raza Malik ₁₆ , Takeshi Saito ₉ , Margery A Connelly ₆ , Naga P Chalasani ₅ , Ramon Bataller ₃ , Z Gordon Jiang ₁

Affiliation

Division of Gastroenterology, Hepatology, and NutritionDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA.
Division of General SurgeryThe Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina.
Division of Gastroenterology, Hepatology, and NutritionUniversity of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA.
Hepatology ProgramCentro de Investigacion Medica Aplicada, Liver UnitClinica Universidad de NavarraInstituto de Investigacion de NavarraUniversity of NavarraPamplonaSpain.
Division of Gastroenterology and HepatologyIndiana University School of MedicineIndianapolisIndianaUSA.
Laboratory Corporation of America HoldingsMorrisvilleNorth CarolinaUSA.
Department of Physiology and BiophysicsBoston University School of MedicineBostonMassachusettsUSA.
Vital TherapiesSan DiegoCaliforniaUSA.
Division of Gastrointestinal and Liver DiseasesKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCaliforniaUSA.
Research and Development DepartmentPhoenixBio, Co., LtdHigashi-Hiroshima, HiroshimaJapan.
Division of Gastroenterology and HepatologyLausanne University Hospital and University of LausanneLausanneSwitzerland.
Transplant InstituteDepartment of SurgeryBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA.
Confocal Imaging Core facilityBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA.
Division of General MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA.
Division of Gastroenterology, Hepatology and NutritionVirginia Commonwealth University School of MedicineRichmondVirginiaUSA.
Liver CenterDivision of GastroenterologyTufts Medical CenterBostonMassachusettsUSA.

Lipoprotein Z (LP-Z) is an abnormal free cholesterol (FC)–enriched LDL-like particle discovered from patients with cholestatic liver disease. This study aims to define the diagnostic value of LP-Z in alcohol-associated hepatitis (AH) and interrogate the biology behind its formation.

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