GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death.

中文翻译：

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GTPase 激活蛋白在调节细胞死亡和肿瘤免疫中的作用

GTPase 激活蛋白 (GAP) 是 GTPase 蛋白的负调节因子，被认为可促进活性 GTPase-GTP 形式向 GTPase-GDP 形式的转化。基于其调节 GTPase 蛋白和其他域的能力，GAP 直接或间接参与各种细胞需求过程。我们回顾了 GAP 调节调节性细胞死亡 (RCD) 的现有证据，主要是细胞凋亡和自噬，以及一些新型 RCD，特别关注它们与疾病，尤其是癌症的关联。我们还认为 GAPs 会影响肿瘤免疫，并试图将 GAPs、RCD 和肿瘤免疫联系起来。更深入地了解调节这些过程的 GAP 可能会导致发现新的治疗靶点，以避免病理性细胞损失或介导癌细胞死亡。