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CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation
Allergy ( IF 12.4 ) Pub Date : 2021-10-17 , DOI: 10.1111/all.15144
Sofia Tagkareli 1 , Maria Salagianni 1 , Ioanna-Evdokia Galani 1 , Maria Manioudaki 1 , Eleftherios Pavlos 1 , Kalliopi Thanopoulou 1 , Evangelos Andreakos 1, 2
Affiliation  

Although FoxP3+ regulatory T (Treg) cells constitute a highly heterogeneous population, with different regulatory potential depending on the disease context, distinct subsets or phenotypes remain poorly defined. This hampers the development of immunotherapy for allergic and autoimmune disorders. The present study aimed at characterizing distinct FoxP3+ Treg subpopulations involved in the suppression of Th2-mediated allergic inflammation in the lung.

中文翻译:

CD103 整合素识别出抑制过敏性气道炎症的高 IL-10 产生 FoxP3+ 调节性 T 细胞群

尽管 FoxP3 +调节性 T (Treg) 细胞构成了一个高度异质的群体,根据疾病背景具有不同的调节潜力,但不同的亚群或表型仍然不明确。这阻碍了针对过敏性和自身免疫性疾病的免疫疗法的发展。本研究旨在表征参与抑制肺部 Th2 介导的过敏性炎症的不同 FoxP3 + Treg 亚群。
更新日期:2021-10-17
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