Polysaccharides are a kind of natural biopolymers and have been widely applied in various fields, especially biomedical applications, due to their fascinating properties, such as renewability, structural diversity, biodegradability and biocompatibility. However, pristine polysaccharides sometimes fail to meet the requirements in biomedical applications. Chemical modifications offer a significant means of changing the physical and chemical properties of polysaccharides and enhancing their functionalities. The traditional modification methods mainly include selective oxidation, carboxymethylation, acetylation, phosphorylation, sulfation, “Click” reactions and polymer grafts. In recent years, mussel-inspired chemistry has emerged as a novel, simple and efficient strategy to modify natural polysaccharides, therefore endowing them with some new and unique properties and broaden their applications in biomedicine. This strategy can give polysaccharides with outstanding adhesive performance, oxidation resistance, antibacterial property, coating capacity, high reactivity, chelating and coordinating abilities, bioactivities, and biological compatibility, and also affords a significant surface modification platform for the fabrication of diverse hybrid materials with specific functionalities. This review summarizes the methods (including surface chemistry and covalent conjugate) to modify various natural polysaccharides (including cellulose, chitin, chitosan, alginate, hyaluronic acid, heparin, starch, etc.) via mussel-inspired chemistry, and discusses their various biomedical applications such as tissue engineering, hemostasis, wound healing, drug delivery, antibacterial, chemo-photothermal therapy, biosensors and 3D bioprinting. This work is expected to give a better understanding of opportunities and challenges of mussel-inspired strategy for the functionalization of polysaccharides in biomedical applications. It can envision that mussel-inspired strategy will continuously attract attention in the modification of polysaccharides and more significant applications will be explored.

多糖是一种天然生物聚合物，因其具有可再生性、结构多样性、生物降解性和生物相容性等迷人特性而被广泛应用于各个领域，尤其是生物医学领域。然而，原始多糖有时无法满足生物医学应用的要求。化学修饰提供了一种改变多糖物理和化学性质并增强其功能的重要手段。传统的改性方法主要包括选择性氧化、羧甲基化、乙酰化、磷酸化、硫酸化、“点击”反应和聚合物接枝等。近年来，受贻贝启发的化学已成为一种新颖、简单且有效的修饰天然多糖的策略，因此赋予它们一些新的和独特的特性，并拓宽它们在生物医学中的应用。该策略可以使多糖具有优异的粘附性能、抗氧化性、抗菌性、涂层能力、高反应性、螯合和配位能力、生物活性和生物相容性，也为制备具有特定特性的多种杂化材料提供了重要的表面改性平台。功能。本综述总结了通过贻贝化学修饰各种天然多糖（包括纤维素、甲壳素、壳聚糖、海藻酸盐、透明质酸、肝素、淀粉等）的方法（包括表面化学和共价缀合物），并讨论了它们的各种生物医学应用如组织工程、止血、伤口愈合、药物输送、抗菌、化学光热疗法、生物传感器和 3D 生物打印。这项工作有望更好地了解贻贝启发的生物医学应用中多糖功能化策略的机遇和挑战。可以预见，受贻贝启发的策略将在多糖修饰方面不断受到关注，并将探索更重要的应用。