The total synthesis of dolabriferol C was achieved by retro-Claisen fragmentation of its putative contiguous precursor, thus establishing the former as a plausible isolation artifact. The carbon skeleton of the precursor was assembled using a novel strategy involving a highly stereoselective three-component bisaldol coupling that sets the absolute configuration of seven (or eight) stereocenters in a one-pot process.

中文翻译：

---

通过内消旋 3,7-二酮与两个手性醛的高度立体选择性一锅偶联全合成 Dolabriferol C

dolabriferol C 的全合成是通过其推定的连续前体的逆克莱森碎裂实现的，从而将前者确立为一个合理的分离工件。前体的碳骨架是使用一种新的策略组装的，该策略涉及高度立体选择性的三组分双醛醇偶联，该策略在一锅法中设置了七个（或八个）立体中心的绝对构型。