Periodontitis could lead to periodontal destruction such as the loss of alveolar bone. The issue that how to achieve the regeneration of alveolar bone and periodontal tissues under the inflammatory environment needs to be solved urgently. Bone morphogenetic protein 9 (BMP9) is one of the most potent osteoinductive BMPs and induces osteogenic differentiation of mesenchymal stem cells. The aim of this study is to explore the possible effect of BMP9 on the osteogenic differentiation of inflammatory periodontal ligament stem cells (PDLSCs).

中文翻译：

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NELL1增强成骨并抑制由BMP9诱导的人牙周膜干细胞的炎症

牙周炎可导致牙周破坏，例如牙槽骨丢失。如何实现炎症环境下牙槽骨和牙周组织的再生是亟待解决的问题。骨形态发生蛋白 9 (BMP9) 是最有效的骨诱导 BMP 之一，可诱导间充质干细胞的成骨分化。本研究的目的是探讨 BMP9 对炎症性牙周膜干细胞 (PDLSCs) 成骨分化的可能影响。