Although dexterity relies on the constant transmission of sensory information, unchecked feedback can be disruptive. Yet how somatosensory feedback from the hands is regulated and whether this modulation influences movement remain unclear. We found that mouse tactile afferents recruit neurons in the brainstem cuneate nucleus, whose activity is modulated by distinct classes of local inhibitory neurons. Manipulation of these inhibitory circuits suppresses or enhances the transmission of tactile information, which affects manual behaviors. Top-down cortical pathways innervate cuneate in a complementary pattern, with somatosensory cortical neurons targeting the core tactile region of cuneate and a large rostral cortical population driving feed-forward inhibition of tactile transmission through an inhibitory shell. These findings identify a circuit basis for tactile feedback modulation that enables the effective execution of dexterous movement.

中文翻译：

---

用于执行灵巧运动的触觉反馈调制

尽管灵巧性依赖于感官信息的不断传递，但未经检查的反馈可能会造成破坏。然而，如何调节来自手的体感反馈以及这种调节是否会影响运动仍不清楚。我们发现小鼠触觉传入神经在脑干楔形核中招募神经元，其活动受不同类别的局部抑制神经元的调节。对这些抑制电路的操纵会抑制或增强触觉信息的传递，从而影响手动行为。自上而下的皮质通路以互补的模式支配楔形，体感皮层神经元靶向楔形的核心触觉区域和一个大的喙侧皮质群，通过抑制壳驱动触觉传递的前馈抑制。