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The prevalence of non-vascular pulmonary manifestations in Takayasu’s Arteritis patients: A Retrospective multi-centred Turkish cohort study
Scandinavian Journal of Rheumatology ( IF 2.1 ) Pub Date : 2021-10-13 , DOI: 10.1080/03009742.2021.1972535
A Yazici 1 , S Kaymaz-Tahra 2 , O Ozdemir Isik 1 , M Kara 3 , N Alpay-Kanitez 4 , O Gerçik 5 , A Omma 6 , S B Kocaer 7 , K Kalkan 8 , N S Yasar Bilgin 9 , K Aksu 3 , G Keser 3 , S Akar 5 , F Onen 7 , H Emmungil 8 , T Kasifoglu 9 , F Alibaz-Oner 2 , H Direskeneli 2 , A Cefle 1
Affiliation  

Objectives

Takayasu’s arteritis (TAK) is a rare vasculitis characterized by inflammation of intermediate- to large-size arteries. Although pulmonary artery involvement (PAI) is an expected finding in some TAK patients, data on non-vascular pulmonary involvement (NVPI) are limited. We aimed to investigate the frequency of NVPI, including parenchymal infiltration, nodules/cavities, pleural effusion, and haemorrhage, in TAK.

Method

We assembled a retrospective cohort of TAK patients from nine tertiary centres in Turkey. The demographics and clinical characteristics of patients were extracted from medical records and the imaging findings were evaluated for pulmonary manifestations.

Results

As of January 2021, 319 TAK patients (female/male 276/43; mean age 42.4 ± 13.5 years) were recruited. Eighty-two patients had cough and/or dyspnoea and four had haemoptysis as pulmonary symptoms. On computed tomography assessment, the overall frequency of NVPI was 7.2%; parenchymal infiltrations were present in 10 (3.1%), pleural effusion in eight (2.5%), nodules/cavities in six (1.9%), and pulmonary haemorrhage in four patients (1.3%). In the whole cohort, 10.3% of patients had pulmonary artery hypertension (PAH) and 5.6% had PAI. Among patients with PAH or PAI, the overall frequency of NVPI was significantly higher than in the rest of the group.

Conclusions

In this TAK cohort from Turkey, we observed NVPI in 7.2% of patients, with parenchymal infiltrations being the most common, followed by pleural effusion. Notably, NVPI was more frequent in patients with PAH or PAI. Although not as common as PAI, NVPI should be kept in mind, especially in TAK patients with PAH or PAI.



中文翻译:

Takayasu 动脉炎患者非血管性肺部表现的患病率:一项回顾性多中心土耳其队列研究

目标

Takayasu 的动脉炎 (TAK) 是一种罕见的血管炎,其特征是中到大动脉的炎症。尽管肺动脉受累 (PAI) 是一些 TAK 患者的预期发现,但非血管性肺受累 (NVPI) 的数据有限。我们旨在调查 TAK 中 NVPI 的频率,包括实质浸润、结节/空洞、胸腔积液和出血。

方法

我们收集了来自土耳其九个三级中心的 TAK 患者的回顾性队列。从病历中提取患者的人口统计学和临床​​特征,并评估影像学表现的肺部表现。

结果

截至 2021 年 1 月,招募了 319 名 TAK 患者(女性/男性 276/43;平均年龄 42.4 ± 13.5 岁)。82 名患者出现咳嗽和/或呼吸困难,4 名患者出现咯血作为肺部症状。在计算机断层扫描评估中,NVPI 的总体频率为 7.2%;10 例 (3.1%) 出现实质浸润,8 例 (2.5%) 出现胸腔积液,6 例 (1.9%) 出现结节/空洞,4 例患者 (1.3%) 出现肺出血。在整个队列中,10.3% 的患者患有肺动脉高压 (PAH),5.6% 的患者患有 PAI。在 PAH 或 PAI 患者中,NVPI 的总体频率显着高于该组其他患者。

结论

在来自土耳其的这个 TAK 队列中,我们在 7.2% 的患者中观察到 NVPI,其中最常见的是实质浸润,其次是胸腔积液。值得注意的是,NVPI 在 PAH 或 PAI 患者中更常见。虽然不如 PAI 常见,但应牢记 NVPI,尤其是在伴有 PAH 或 PAI 的 TAK 患者中。

更新日期:2021-10-13
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