Nanoparticle-based therapeutics have the potential to change the paradigm of how we approach the diagnosis and treatment of human disease. Employing naturally derived cell membranes as a surface coating has created a powerful new approach by which nanoparticles can be functionalized towards a wide range of biomedical applications. By using membranes derived from different cell sources, the resulting nanoparticles inherit properties that can make them well-suited for a variety of tasks. In recent years, stimuli-responsive platforms with the ability to release payloads on demand have received increasing attention due to their improved delivery, reduced side effects, and precision targeting. Nanoformulations have been developed to respond to external stimuli such as magnetic fields, ultrasound, and radiation, as well as local stimuli such as pH gradients, redox potentials, and other chemical conditions. Here, an overview of the novel cell membrane coating platform is provided, followed by a discussion of stimuli-responsive platforms that leverage this technology.

基于纳米粒子的疗法有可能改变我们诊断和治疗人类疾病的方式。使用天然衍生的细胞膜作为表面涂层创造了一种强大的新方法，通过该方法纳米粒子可以针对广泛的生物医学应用进行功能化。通过使用来自不同细胞来源的膜，由此产生的纳米粒子继承了可以使其非常适合各种任务的特性。近年来，能够按需释放有效载荷的刺激响应平台因其改进的交付、减少的副作用和精确的目标而受到越来越多的关注。已经开发出纳米制剂来响应外部刺激，例如磁场、超声波和辐射，以及局部刺激，例如 pH 梯度、氧化还原电位和其他化学条件。在这里，提供了新型细胞膜涂层平台的概述，然后讨论了利用该技术的刺激响应平台。