Shigella is a highly infectious human pathogen, yet mice are naturally resistant to infection. In this issue of Cell Host & Microbe, Luchetti et al. (2021) discuss this species specificity, demonstrating that Shigella directly targets the pore-forming protein Gasdermin D for degradation, thus preventing pyroptosis to enable infection of human cells.

中文翻译：

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志贺氏菌关闭了烟火技术表演

志贺氏菌是一种高度传染性的人类病原体，但小鼠对感染具有天然抵抗力。在本期Cell Host & Microbe 中，Luchetti 等人。(2021) 讨论了这一物种特异性，证明志贺氏菌直接靶向成孔蛋白 Gasdermin D 进行降解，从而防止细胞焦亡以感染人类细胞。