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From Memories of Past Experiences to Present Motivation? A Meta-analysis on the Association Between Episodic Memory and Negative Symptoms in People With Psychosis
Schizophrenia Bulletin ( IF 6.6 ) Pub Date : 2021-10-12 , DOI: 10.1093/schbul/sbab120
Matthias Pillny 1 , Katarina Krkovic 1 , Laura Buck 1 , Tania M Lincoln 1
Affiliation  

Abstract
Based on findings from cognitive science, it has been theorized that the reductions in motivation and goal-directed behavior in people with psychosis could stem from impaired episodic memory. In the current meta-analysis, we investigated this putative functional link between episodic memory deficits and negative symptoms. We hypothesized that episodic memory deficits in psychosis would be related to negative symptoms in general but would be more strongly related to amotivation than to reduced expressivity. We included 103 eligible studies (13,622 participants) in the analyses. Results revealed significant, moderate negative associations of episodic memory with negative symptoms in general (k = 103; r = −.23; z = −13.40; P ≤ .001; 95% CI [−.26; −.20]), with amotivation (k = 16; r = −.18; z = −6.6; P ≤ .001; 95% CI [−.23; −.13]) and with reduced expressivity (k = 15; r = −.18; z = −3.30; P ≤.001; 95% CI[−.29; −.07]). These associations were not moderated by sociodemographic characteristics, positive symptoms, depression, antipsychotic medication or type of negative symptom scale. Although these findings provide sound evidence for the association between episodic memory deficits and amotivation, the rather small magnitude and the unspecific pattern of this relationship also indicate that episodic memory deficits are unlikely to be the only factor relevant to amotivation. This implicates that future research should investigate episodic memory in conjunction with other factors that could account for the association of episodic memory deficits and amotivation in psychosis.


中文翻译:

从过去经历的记忆到现在的动机?精神病患者情景记忆与负面症状相关性的Meta分析

摘要
根据认知科学的发现,理论上认为精神病患者动机和目标导向行为的减少可能源于情景记忆受损。在当前的荟萃分析中,我们调查了情景记忆缺陷和阴性症状之间的这种假定的功能联系。我们假设精神病中的情景记忆缺陷通常与阴性症状有关,但与动机缺乏相关性比与表达能力降低的相关性更强。我们在分析中纳入了 103 项符合条件的研究(13,622 名参与者)。结果显示,情节记忆与一般阴性症状显着、中度负相关(k = 103;r = -.23;z = -13.40;P≤ .001;95% CI [−.26; -.20]),缺乏动力(k = 16;r = -.18;z = -6.6;P ≤ .001;95% CI [-.23;-.13])和表达能力降低(k = 15 ; r = -.18; z = -3.30; P≤.001;95% CI[−.29; −.07])。这些关联不受社会人口学特征、阳性症状、抑郁、抗精神病药物或阴性症状量表类型的影响。尽管这些发现为情景记忆缺陷和动机之间的关联提供了充分的证据,但这种关系的相当小的幅度和非特异性模式也表明情景记忆缺陷不太可能是与动机无关的唯一因素。这意味着未来的研究应该结合其他因素来研究情景记忆,这些因素可以解释情景记忆缺陷和精神病中的动机不足的关联。
更新日期:2021-10-12
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