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The Ensembl COVID-19 resource: ongoing integration of public SARS-CoV-2 data
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2021-09-20 , DOI: 10.1093/nar/gkab889
Nishadi H De Silva 1 , Jyothish Bhai 1 , Marc Chakiachvili 1 , Bruno Contreras-Moreira 1 , Carla Cummins 1 , Adam Frankish 1 , Astrid Gall 1 , Thiago Genez 1 , Kevin L Howe 1 , Sarah E Hunt 1 , Fergal J Martin 1 , Benjamin Moore 1 , Denye Ogeh 1 , Anne Parker 1 , Andrew Parton 1 , Magali Ruffier 1 , Manoj Pandian Sakthivel 1 , Dan Sheppard 1 , John Tate 1 , Anja Thormann 1 , David Thybert 1 , Stephen J Trevanion 1 , Andrea Winterbottom 1 , Daniel R Zerbino 1 , Robert D Finn 1 , Paul Flicek 1 , Andrew D Yates 1
Affiliation  

The COVID-19 pandemic has seen unprecedented use of SARS-CoV-2 genome sequencing for epidemiological tracking and identification of emerging variants. Understanding the potential impact of these variants on the infectivity of the virus and the efficacy of emerging therapeutics and vaccines has become a cornerstone of the fight against the disease. To support the maximal use of genomic information for SARS-CoV-2 research, we launched the Ensembl COVID-19 browser; the first virus to be encompassed within the Ensembl platform. This resource incorporates a new Ensembl gene set, multiple variant sets, and annotation from several relevant resources aligned to the reference SARS-CoV-2 assembly. Since the first release in May 2020, the content has been regularly updated using our new rapid release workflow, and tools such as the Ensembl Variant Effect Predictor have been integrated. The Ensembl COVID-19 browser is freely available at https://covid-19.ensembl.org.

中文翻译:

Ensembl COVID-19 资源:公共 SARS-CoV-2 数据的持续整合

在 COVID-19 大流行中,SARS-CoV-2 基因组测序被前所未有地用于流行病学跟踪和新出现变异的识别。了解这些变异对病毒感染性以及新兴疗法和疫苗功效的潜在影响已成为抗击该疾病的基石。为了支持最大限度地利用基因组信息进行 SARS-CoV-2 研究,我们推出了 Ensembl COVID-19 浏览器;Ensembl 平台中包含的第一个病毒。该资源包含一个新的 Ensembl 基因集、多个变体集以及来自与参考 SARS-CoV-2 组装一致的多个相关资源的注释。自 2020 年 5 月首次发布以来,我们使用新的快速发布工作流程定期更新内容,并集成了 Ensembl Variant Effect Predictor 等工具。Ensembl COVID-19 浏览器可在 https://covid-19.ensembl.org 上免费获取。
更新日期:2021-09-20
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