Diabetic wounds are difficult to heal due to recurrent bacterial infection, decreased proliferation, and migration of epidermal and endothelial cells. This is related to impaired leukocyte function and low blood concentrations of H₂S in diabetic patients. Herein, an antibacterial polymersome-based wound dressing spray was demonstrated for complete diabetic wound healing. The designed polymersome was self-assembled from poly(ε-caprolactone)₂₄-block-poly[lysine₁₅-stat-(S-aroylthiooxime)₂₃] [PCL₂₄-b-P(Lys₂₃-stat-SATO₁₅)], where PCL is the hydrophobic membrane-forming block and P(Lys-stat-SATO) acts as a hydrophilic stabilizer block. The polymersomes can penetrate and kill Gram-positive and Gram-negative bacteria because of the electrostatic interaction induced by the antibacterial P(Lys₂₃-stat-SATO₁₅) block. Furthermore, the SATO segments are capable of long-term H₂S generation by reacting with cysteine (up to 12 h). This promotes proliferation, migration of epidermal and endothelial cells, and angiogenesis. Overall, this polymersome-based wound dressing spray acts as a bacterial inhibitor and H₂S generator and offers a fresh insight into the effective treatment of diabetic wounds.

中文翻译：

---

能够抑制细菌和产生 H2S 以实现糖尿病伤口完全愈合的聚合物伤口敷料喷雾

由于反复的细菌感染、增殖减少以及表皮和内皮细胞的迁移，糖尿病伤口难以愈合。这与糖尿病患者的白细胞功能受损和H ₂ S 的低血液浓度有关。在此，基于抗菌聚合物体的伤口敷料喷雾被证明可用于糖尿病伤口的完全愈合。所设计的聚合物囊泡是自组装从聚（ε己内酯）₂₄ -嵌段-聚[赖氨酸₁₅ - STAT - （小号-aroylthiooxime）₂₃ ] [PCL ₂₄ - b -P（LYS ₂₃ - STAT -SATO ₁₅）]，其中PCL是疏水性膜形成块和P（赖氨酸- STAT -SATO）充当亲水性稳定块。由于抗菌 P(Lys ₂₃ - stat -SATO ₁₅ ) 块诱导的静电相互作用，聚合物囊泡可以穿透并杀死革兰氏阳性菌和革兰氏阴性菌。此外，SATO 片段能够通过与半胱氨酸反应（最多 12 小时）长期产生H ₂ S。这促进了表皮和内皮细胞的增殖、迁移和血管生成。总体而言，这种基于聚合物囊泡的伤口敷料喷雾剂可作为细菌抑制剂和 H ₂ S 发生器，为糖尿病伤口的有效治疗提供了新的见解。