Studies on the sporadic form of Alzheimer’s disease (AD) have revealed three classes of risk factor: age, genetics, and sex. These risk factors point to a metabolic dysregulation as the origin of AD. Adaptive alterations in cerebral metabolism are the rationale for the Metabolic Reprogramming (MR) Theory of the origin of AD. The theory contends that the progression toward AD involves three adaptive events: a hypermetabolic phase, a prolonged prodromal phase, and a metabolic collapse. This article exploits the MR Theory to elucidate the effect of hormonal changes on the origin and progression of AD in women. The theory invokes bioenergetic signatures of the menopausal transition to propose sex-specific diagnostic program and therapeutic strategies.

对偶发性阿尔茨海默病 (AD) 的研究揭示了三类风险因素：年龄、遗传和性别。这些风险因素表明代谢失调是 AD 的起源。脑代谢的适应性改变是 AD 起源的代谢重编程 (MR) 理论的基本原理。该理论认为，向 AD 的进展涉及三个适应性事件：高代谢期、延长的前驱期和代谢崩溃。本文利用 MR 理论来阐明激素变化对女性 AD 起源和进展的影响。该理论利用更年期过渡的生物能量特征来提出性别特异性诊断方案和治疗策略。