An unprecedented asymmetric cascade allylation/lactonization between racemic aldimine esters and racemic vinylethylene carbonate catalyzed by synergistic Cu/Ir catalysis is presented. The metalated azomethine ylide acts as a two-atom unit and opens up access to a broad range of γ-butyrolactones bearing two vicinal stereogenic centers in a stereodivergent manner.

中文翻译：

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铜和铱协同催化下具有两个邻位立体中心的对映体富集γ-丁内酯的立体发散合成

外消旋醛亚胺酯和外消旋乙烯基碳酸亚乙酯之间发生了前所未有的不对称级联烯丙基化/内酯化反应，由协同 Cu/Ir 催化催化。金属化的偶氮甲碱叶立德作为一个双原子单元，以立体发散的方式打开了对带有两个邻位立体中心的广泛 γ-丁内酯的访问。