Site-Specific 5-Formyl Cytosine Mediated DNA-Histone Cross-Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η,Angewandte Chemie International Edition

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Site-Specific 5-Formyl Cytosine Mediated DNA-Histone Cross-Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2021-10-11 , DOI: 10.1002/anie.202109418
Suresh S Pujari ₁ , Mingxuan Wu _{2,

3} , Jenna Thomforde ₁ , Zhipeng A Wang ₂ , Christopher Chao ₁ , Noelle M Olson ₄ , Luke Erber ₁ , William C K Pomerantz ₄ , Philip Cole ₂ , Natalia Y Tretyakova ₁

Affiliation

DNA–histone cross-links (DPCs) have been synthesized efficiently via oxime ligation. These DPC lesions block DNA replication but the replication block can be removed via proteolytic processing.