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Worse Hospital Outcomes for Children and Adults with COVID-19 and Congenital Heart Disease
Pediatric Cardiology ( IF 1.6 ) Pub Date : 2021-10-11 , DOI: 10.1007/s00246-021-02751-6
Danielle D Strah 1 , Katie A Kowalek 2 , Kevin Weinberger 1 , Jenny Mendelson 2 , Andrew W Hoyer 3 , Scott E Klewer 3 , Michael D Seckeler 3
Affiliation  

The aim of the current study is to investigate hospitalization outcomes of COVID-19 positive children and adults with moderate or severe congenital heart disease to children and adults without congenital heart disease. Retrospective review using the Vizient Clinical Data Base for admissions of patients with an ICD-10 code for COVID-19 from April 2020 to March 2021. Admissions with COVID-19 and with and without moderate or severe congenital heart disease (CHD) were stratified into pediatric (< 18 years) and adult (≥ 18 years) and hospital outcomes were compared. There were 9478 pediatric COVID-19 admissions, 160 (1.7%) with CHD, and 658,230 adult COVID-19 admissions, 389 (0.06%) with CHD. Pediatric admissions with COVID-19 and CHD were younger (1 vs 11 years), had longer length of stay (22 vs 6 days), higher complication rates (6.9 vs 1.1%), higher mortality rates (3.8, 0.8%), and higher costs ($54,619 vs 10,731; p < 0.001 for all). Adult admissions with COVID-19 and CHD were younger (53 vs 64 years, p < 0.001), had longer length of stay (12 vs 9 days, p < 0.001), higher complication rates (8 vs 4.8%, p = 0.003), and higher costs ($23,551 vs 13,311, p < 0.001). This appears to be the first study to report the increased hospital morbidities and costs for patients with CHD affected by COVID-19. Our hope is that these findings will help counsel patients moving forward during the pandemic.



中文翻译:

患有 COVID-19 和先天性心脏病的儿童和成人的医院结局更差

本研究的目的是调查 COVID-19 阳性儿童和成人患有中度或重度先天性心脏病的住院结局与没有先天性心脏病的儿童和成人的住院结局。使用 Vizient 临床数据库对 2020 年 4 月至 2021 年 3 月 COVID-19 的 ICD-10 代码入院患者进行回顾性审查。COVID-19 入院以及有和没有中度或重度先天性心脏病 (CHD) 的入院被分层为比较了儿童(< 18 岁)和成人(≥ 18 岁)和医院的结局。有 9478 例儿童 COVID-19 入院,160 例(1.7%)患有 CHD,658,230 例成人 COVID-19 入院,389 例(0.06%)患有 CHD。患有 COVID-19 和 CHD 的儿科患者更年轻(1 岁对 11 岁),住院时间更长(22 天对 6 天),并发症发生率更高(6.9% 对 1.1%),所有p  < 0.001)。患有 COVID-19 和 CHD 的成人患者更年轻(53 岁对 64 岁,p  < 0.001),住院时间更长(12 天对 9 天,p  < 0.001),并发症发生率更高(8 对 4.8%,p  = 0.003) ,以及更高的成本(23,551 美元对 13,311 美元,p  < 0.001)。这似乎是第一项报告受 COVID-19 影响的 CHD 患者住院发病率和费用增加的研究。我们希望这些发现将帮助患者在大流行期间向前迈进。

更新日期:2021-10-12
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