This study investigates if genetic factors could contribute to the high rate of mood disorders reported in a U.S. community known to have a restricted early founder population (confirmed here through runs of homozygosity analysis). Polygenic scores (PGSs) for eight common diseases, disorders, or traits, including psychiatric disorders, were calculated in 274 participants (125 mood disorder cases) who each reported three or four grandparents born in the community. Ancestry-matched controls were selected from the UK Biobank (UKB; three sets of N = 1,822 each). The mean PGSs were significantly higher in the community for major depression PRS (p = 2.1 × 10-19 , 0.56 SD units), bipolar disorder (p = 2.5 × 10-15 , 0.56 SD units), and schizophrenia (p = 3.8 × 10-21 , 0.64 SD units). The PGSs were not significantly different between the community participants and UKB controls for the traits of body mass index, Type 2 diabetes, coronary artery disease, and chronotype. The mean PGSs for height were significantly lower in the community sample compared to controls (-0.21 SD units, p = 1.2 × 10-5 ). The results are consistent with enrichment of polygenic risk factors for psychiatric disorders in this community.

中文翻译：

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多基因负担可以解释创始人人口有限的社区中情感障碍的高发病率。

这项研究调查了遗传因素是否可能导致美国社区报告的高发病率情绪障碍，该社区已知早期创始人人口有限（通过纯合性分析在此确认）。在 274 名参与者（125 例情绪障碍病例）中计算了八种常见疾病、障碍或特征（包括精神疾病）的多基因评分 (PGS)，每名参与者报告了三到四名在社区出生的祖父母。祖先匹配的对照选自英国生物库（UKB；三组 N = 1,822，每组）。社区中重性抑郁症 PRS（p = 2.1 × 10-19, 0.56 SD 单位）、双相情感障碍（p = 2.5 × 10-15, 0.56 SD 单位）和精神分裂症（p = 3.8 × 10-21 , 0.64 SD 单位)。社区参与者和 UKB 对照的 PGS 在体重指数、2 型糖尿病、冠状动脉疾病和表型特征方面没有显着差异。与对照组相比，社区样本中身高的平均 PGS 显着降低（-0.21 SD 单位，p = 1.2 × 10-5）。结果与该社区精神疾病多基因危险因素的丰富一致。