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Can gut microbes predict efficacy and toxicity of combined immune checkpoint blockade?
Cancer Cell ( IF 50.3 ) Pub Date : 2021-10-11 , DOI: 10.1016/j.ccell.2021.09.013
Khiem C Lam 1 , Romina S Goldszmid 1
Affiliation  

A recent report in Nature Medicine pinpoints a role for gut microbiota in response and toxicity to combined immune checkpoint blockade targeting CTLA-4 and PD-1. This emergent study provides insights that can be used to leverage microbiota in the design of anticancer therapies to mitigate toxicity while enhancing efficacy.



中文翻译:

肠道微生物能否预测联合免疫检查点阻断的疗效和毒性?

Nature Medicine最近的一份报告指出了肠道微生物群在针对 CTLA-4 和 PD-1 的联合免疫检查点阻断的反应和毒性中的作用。这项新兴研究提供的见解可用于在设计抗癌疗法时利用微生物群来减轻毒性,同时提高疗效。

更新日期:2021-10-11
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