Background. Gingivitis and periodontitis are prevalent inflammatory diseases of the periodontal tissues. Current treatments are often ineffective or do not prevent disease recurrence. Uncontrolled complement activation and the resulting chronic gingival inflammation are hallmarks of periodontal diseases. We determined the efficacy and safety of a complement 3–targeted therapeutic, AMY-101, which was locally administered to adult patients with periodontal inflammation.

中文翻译：

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补体 C3 抑制剂 AMY-101 在成人牙周炎患者中的 IIa 期临床试验

背景。牙龈炎和牙周炎是牙周组织常见的炎症性疾病。目前的治疗通常无效或不能预防疾病复发。不受控制的补体激活和由此产生的慢性牙龈炎症是牙周病的标志。我们确定了补体 3 靶向治疗剂 AMY-101 的疗效和安全性，该治疗剂局部给药于患有牙周炎的成年患者。