Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, and knowledge of the methyllysine binding mechanisms.

中文翻译：

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寻找甲基赖氨酸结合芳香笼

赖氨酸残基的甲基化在多种细胞信号传导过程中起着至关重要的作用。虽然细胞核中阅读域识别甲基化组蛋白的生物学重要性已得到充分证实，但与非组蛋白甲基化相关的过程，特别是在细胞质中，尚不清楚。在这里，我们描述了使用快速结构基序挖掘算法 Erebus、PDB 数据库和甲基赖氨酸结合机制的知识来搜索潜在的甲基赖氨酸阅读器。