The critical event in KRAS signaling and oncogenic transformation is activation of the RAF–MEK–MAPK cascade. This requires assembly of a multiprotein–lipid complex on the plasma membrane. In a tour de force of modeling, Mysore et al. now provide the first glimpse of what this structure may actually look like.

中文翻译：

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深入了解 KRAS 信号复合体

KRAS 信号传导和致癌转化中的关键事件是 RAF-MEK-MAPK 级联的激活。这需要在质膜上组装多蛋白-脂质复合物。在建模的杰作中，Mysore 等人。现在提供这个结构的实际外观的第一眼。