Background/aims Fetal haemoglobin (HbF) has an oxyhaemoglobin dissociation curve that may affect systemic oxygenation and the development of retinopathy of prematurity (ROP). The study aim is to characterise the effects of HbF levels on systemic oxygenation and ROP development. Methods Prospective study conducted from 1 September 2017 through 31 December 2018 at the Johns Hopkins NICU. Preterm infants with HbF measured at birth, 31, 34 and 37 weeks post-menstrual age (PMA), complete blood gas and SpO2 recorded up to 42 weeks PMA, and at least one ROP exam were included. Results Sixty-four preterm infants were enrolled. Higher HbF was associated with significantly higher SpO2, lower PCO2, lower FiO2 from birth to 31 weeks PMA and 31 to 34 weeks PMA (rs=0.51, rs=−0.62 and rs=−0.63; p<0.0001 and rs=0.71, rs=−0.58 and rs=−0.79; p<0.0001, respectively). To maintain oxygen saturation goals set by the neonatal intensive care unit, higher median FiO2 was required for HbF in the lowest tercile from birth compared with HbF in the highest tercile to 31 weeks and 31 to 34 weeks PMA; FiO2=35 (21–100) versus 21 (21–30) p<0.006 and FiO2=30 (28–100) versus 21 (21–30) p<0.001, respectively. Preterm infants with ROP had poorer indices of systemic oxygenation, as measured by median levels of SpO2 and PCO2, and lower levels of HbF (p<0.039 and p<0.0001, respectively) up to 34 weeks PMA. Conclusion Low HbF levels correlated with poor oxygenation indices and increased risk for ROP. O2 saturation goals to prevent ROP may need to incorporate relative amount of HbF. All data relevant to the study are included in the article or uploaded as online supplemental information. All data relevant to this study are included in the article.

中文翻译：

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胎儿血红蛋白对早产儿全身氧合作用和早产儿视网膜病变发展的影响 PacIFiHER 报告第 2 号

背景/目的 胎儿血红蛋白 (HbF) 具有氧合血红蛋白解离曲线，可能影响全身氧合作用和早产儿视网膜病变 (ROP) 的发展。该研究的目的是表征 HbF 水平对全身氧合和 ROP 发展的影响。方法 2017 年 9 月 1 日至 2018 年 12 月 31 日在约翰霍普金斯新生儿重症监护室进行的前瞻性研究。早产儿在出生时、月经后 31、34 和 37 周时测量 HbF，全血气和 SpO2 记录长达 42 周 PMA，并且包括至少一次 ROP 检查。结果 64 名早产儿被纳入研究。从出生到 31 周 PMA 和 31 至 34 周 PMA，较高的 HbF 与显着较高的 SpO2、较低的 PCO2、较低的 FiO2 相关（rs=0.51，rs=-0.62 和 rs=-0.63；p<0.0001 和 rs=0.71，rs =−0.58 和 rs=−0.79；p<0.0001，分别）。为了维持新生儿重症监护病房设定的氧饱和度目标，与最高 31 周和 31 至 34 周 PMA 的 HbF 相比，从出生起最低 tercile 的 HbF 需要更高的中值 FiO2；FiO2=35 (21–100) 对比 21 (21–30) p<0.006 和 FiO2=30 (28–100) 对比 21 (21–30) p<0.001。根据 SpO2 和 PCO2 的中值水平测量，患有 ROP 的早产儿的全身氧合指数较差，并且 HbF 水平较低（分别为 p<0.039 和 p<0.0001）直至 PMA 34 周。结论 低 HbF 水平与氧合指数差和 ROP 风险增加相关。防止 ROP 的 O2 饱和目标可能需要结合相对量的 HbF。与研究相关的所有数据都包含在文章中或作为在线补充信息上传。