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Interleukin 6 predicts increased neural response during face processing in a sample of individuals with schizophrenia and healthy participants: A functional magnetic resonance imaging study
NeuroImage: Clinical ( IF 4.2 ) Pub Date : 2021-10-07 , DOI: 10.1016/j.nicl.2021.102851
David Mothersill 1 , Sinead King 2 , Laurena Holleran 2 , Maria Dauvermann 3 , Saahithh Patlola 2 , Karolina Rokita 2 , Ross McManus 4 , Marcus Keynon 4 , Colm McDonald 5 , Brian Hallahan 5 , Aiden Corvin 4 , Derek Morris 6 , John Kelly 7 , Declan McKernan 7 , Gary Donohoe 2
Affiliation  

Background

Deficits in facial emotion recognition are a core feature of schizophrenia and predictive of functional outcome. Higher plasma levels of the cytokine interleukin 6 (IL-6) have recently been associated with poorer facial emotion recognition in individuals with schizophrenia and healthy participants, but the neural mechanisms affected remain poorly understood.

Methods

Forty-nine individuals with schizophrenia or schizoaffective disorder and 158 healthy participants were imaged using functional magnetic resonance imaging during a dynamic facial emotion recognition task. Plasma IL-6 was measured from blood samples taken outside the scanner. Multiple regression was used in statistical parametric mapping software to test whether higher plasma IL-6 predicted increased neural response during task performance.

Results

Higher plasma IL-6 predicted increased bilateral medial prefrontal response during neutral face processing compared to angry face processing in the total sample (N = 207, tmax = 5.67) and increased left insula response during angry face processing compared to neutral face processing (N = 207, tmax = 4.40) (p < 0.05, family-wise error corrected across the whole brain at the cluster level).

Conclusions

These findings suggest that higher peripheral IL-6 levels predict altered neural response within brain regions involved in social cognition and emotion during facial emotion recognition. This is consistent with recent neuroimaging research on IL-6 and suggesting a possible neural mechanism by which this cytokine might affect facial emotion recognition accuracy.



中文翻译:

白细胞介素 6 预测精神分裂症患者和健康参与者样本在面部处理过程中的神经反应增加:一项功能性磁共振成像研究

背景

面部情绪识别的缺陷是精神分裂症的核心特征和功能结果的预测。最近,较高的血浆细胞因子白细胞介素 6 (IL-6) 水平与精神分裂症患者和健康参与者的面部情绪识别较差有关,但受影响的神经机制仍然知之甚少。

方法

在动态面部情绪识别任务期间,使用功能性磁共振成像对 49 名精神分裂症或分裂情感障碍患者和 158 名健康参与者进行了成像。从扫描仪外采集的血样中测量血浆 IL-6。在统计参数映射软件中使用多元回归来测试较高的血浆 IL-6 是否预测任务执行期间神经反应的增加。

结果

在总样本中,较高的血浆 IL-6 预测在中性脸处理过程中双侧内侧前额叶响应增加(N = 207,t max  = 5.67),并且与中性脸处理相比,在愤怒脸处理过程中左脑岛反应增加(N = 207, t max  = 4.40) (p < 0.05, 在集群级别在整个大脑中纠正了家庭错误)。

结论

这些发现表明,较高的外周 IL-6 水平可预测面部情绪识别过程中涉及社会认知和情绪的大脑区域内的神经反应改变。这与最近对 IL-6 的神经影像学研究一致,并表明这种细胞因子可能影响面部情绪识别准确性的一种可能的神经机制。

更新日期:2021-10-09
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