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Stress-responsive transcription factors train stem cells to remember
Cell Stem Cell ( IF 23.9 ) Pub Date : 2021-10-07 , DOI: 10.1016/j.stem.2021.09.005
Tram Mai Nguyen 1 , Mariaceleste Aragona 1
Affiliation  

In this issue of Cell Stem Cell, Larsen et al. (2021) reveal the molecular machinery that empowers epidermal stem cells to remember. They find that STAT3 and AP1 family establish memory, enabling JUN to remain on the open chromatin and allowing fast recruitment of FOS in case of a second attack.



中文翻译:

应激反应转录因子训练干细胞记忆

在本期《细胞干细胞》中, Larsen 等人。(2021) 揭示了赋予表皮干细胞记忆能力的分子机制。他们发现 STAT3 和 AP1 家族建立记忆,使 JUN 能够保持在开放的染色质上,并允许在第二次攻击时快速募集 FOS。

更新日期:2021-10-08
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