Physical-function derived cut-points for the diagnosis of sarcopenia and dynapenia from the Canadian Longitudinal Study on Aging.

Volume 10, Issue 5, pages: 985–999.

First published online: July 15, 2019.

In the original full paper,¹ appendicular lean mass data obtained from the CLSA inadvertently included bone mineral content. Because sarcopenia is typically defined by low appendicular soft lean mass (without bone), cut-points to identify sarcopenia were overestimated. Bone mineral content data were subsequently obtained from the CLSA and subtracted from lean mass for correction; all original analyses were repeated.

Correct appendicular (soft) lean mass and index values are found in Table 1. Cut-points for low appendicular (soft) lean mass are 7.31 kg/m² in men and 5.43 kg/m² in women (Figure 3). This correction impacted mostly descriptive data by sarcopenia category and estimations of sarcopenia prevalence in this cohort (Tables 2 and 3; Suppl. Figure 2), and in comparison to other cohorts (Tables 4 and 5). However, the correction did not affect the relationships between low appendicular lean soft mass, handgrip strength and physical function (Figure 1) and therefore, the original interpretation of data and conclusions remain.

Table 2. Sensitivity analysis for strength as a predictor of limited physical performance and for low ALM as a predictor of low strength across subgroups in the CLSA cohort, 2011–2015

• HGS, handgrip strength; ALMI, appendicular lean mass index; SCREEN II-AB, abbreviated Seniors in the community risk evaluation for eating and nutrition, version II, score < 38 was considered as at risk of poor nutritional state; COPD, chronic obstructive pulmonary diseases.
• ¹ Interaction for absence/presence of low HGS and subgroup characteristics in the prediction of impaired physical performance.
• ² Interaction for absence/presence of low ALM and subgroup characteristics in the prediction of low HGS.

Table 3. Baseline characteristics of men and women by absence or presence of sarco-dynapenia applying Canadian longitudinal study on aging cut-points, 2011–2015

• Values are mean ± SD. ALM, appendicular lean mass; BMI, body mass index; PASE, Physical Activity Scale for Elderly; SCREEN II-AB, abbreviated Seniors in the Community Risk Evaluation for Eating and Nutrition, version II; TUG, timed-up-and-go. Mann–Whitney U test unless otherwise specified.
• ^a Independent t-test;
• ^b Chi-square test
• * P-value < 0.05;
• ** P-value < 0.001;

Table 4. Descriptive statistics between men with presence or absence of low ALM applying the new Canadian and the FNIH cut-points, in the Canadian longitudinal study on aging cohort

• Values are mean ± SD. ALM, appendicular lean mass; BMI, body mass index; FNIH, Foundation for the National Institute of Health; PASE, Physical Activity Scale for Elderly; SCREEN II-AB, abbreviated Seniors in the Community Risk Evaluation for Eating and Nutrition, version II; TUG, timed-up-and-go.
• ^a From Mann–Whitney U test unless otherwise specified; ^b Independent t-test; ^c Chi-square test.

Table 5. Descriptive statistics between women with presence or absence of low ALM applying the new Canadian and the FNIH cut-points, in the Canadian longitudinal study on aging cohort

• Values are mean ± SD. ALM, appendicular lean mass; BMI, body mass index; FNIH, Foundation for the National Institute of Health; PASE, Physical Activity Scale for Elderly; SCREEN II-AB, abbreviated Seniors in the Community Risk Evaluation for Eating and Nutrition, version II; TUG, timed up-and-go.
• ^a From Mann–Whitney U test unless otherwise specified.
• ^b Independent t-test.
• ^c Chi-square test.

Corrected data are identified in red font in Tables 1-5 below, Figure 3, Supplemental Figure 2 and in the article text:

来自加拿大老龄化纵向研究的用于诊断肌肉减少症和肌肉减少症的身体功能切点。

第 10 卷，第 5 期，第 985-999 页。

首次在线发布：2019 年 7 月 15 日。

在原始全文中，从 CLSA 获得的^{1 个}附肢瘦体重数据无意中包含了骨矿物质含量。因为肌肉减少症通常由低四肢软瘦体重（无骨）定义，所以识别肌肉减少症的切点被高估了。随后从 CLSA 获得骨矿物质含量数据，并从瘦体重中减去以进行校正；重复所有原始分析。

正确的附肢（软）瘦体重和指数值见表 1。低附肢（软）瘦体重的分界点是男性7.31 kg/m ²和女性5.43 kg/m ²（图 3）。这种校正主要影响了按肌肉减少症类别的描述性数据和该队列中肌肉减少症患病率的估计（表 2 和 3；补充图 2），以及与其他队列的比较（表 4 和 5）。然而，校正不影响低四肢瘦软质量、握力和身体功能之间的关系（图 1），因此，数据和结论的原始解释仍然存在。

表 2. 2011-2015 年 CLSA 队列中，力量作为有限体能预测指标和低 ALM 作为低力量预测指标的敏感性分析

• HGS，握力；ALMI，阑尾瘦体重指数；SCREEN II-AB，在社区饮食和营养风险评估中缩写为老年人，版本 II，得分 < 38 被认为有营养不良的风险；COPD，慢性阻塞性肺疾病。
• ¹ 在预测身体机能受损时，低 HGS 的缺失/存在与亚组特征的相互作用。
• ² 低 ALM 的缺失/存在与低 HGS 预测中的亚组特征的相互作用。

表 3. 2011 年至 2015 年应用加拿大纵向研究老化切点的男性和女性的基线特征（按是否存在肌肉运动障碍）

• 值是平均值±SD。ALM，阑尾瘦体重；BMI，体重指数；PASE，老年人体力活动量表；SCREEN II-AB，在社区饮食和营养风险评估中缩写为老年人，第二版；TUG，定时启动。除非另有说明，否则Mann-Whitney U检验。
• ^一个 独立吨-test;
• ^b 卡方检验
• * P值 < 0.05；
• ** P值 < 0.001；

表 4.在加拿大老龄化队列纵向研究中，应用新的加拿大和 FNIH 切点的存在或不存在低 ALM 的男性之间的描述性统计数据

• 值是平均值±SD。ALM，阑尾瘦体重；BMI，体重指数；FNIH，美国国立卫生研究院基金会；PASE，老年人体力活动量表；SCREEN II-AB，在社区饮食和营养风险评估中缩写为老年人，第二版；TUG，定时启动。
• ^a 除非另有说明，否则来自 Mann-Whitney U检验；^b独立 t 检验；^c卡方检验。

表 5.在加拿大老龄化队列纵向研究中应用新的加拿大和 FNIH 切点的存在或不存在低 ALM 的女性之间的描述性统计数据

• 值是平均值±SD。ALM，阑尾瘦体重；BMI，体重指数；FNIH，美国国立卫生研究院基金会；PASE，老年人体力活动量表；SCREEN II-AB，在社区饮食和营养风险评估中缩写为老年人，第二版；TUG，定时启动。
• ^a 除非另有说明，否则来自 Mann-Whitney U检验。
• ^b 独立 t 检验。
• ^c 卡方检验。

更正后的数据在下面的表 1-5、图 3、补充图 2 和文章正文中以红色字体标识：