Citrus reticulata ‘Huajuhong’ (HJH) and C. reticulata ‘Sanhuhongju’ (SHHJ) have distinct level of bioactive ingredients including flavonoid derivatives in peels meanwhile its underlying mechanism remain unclear. Integrated analysis of metabolome and transcriptome was comparatively investigated differences of HJH and SHHJ peels. The total flavonoid in HJH peels was significantly higher than that in SHHJ. Of 203 differentially accumulated metabolites (DAMs) and 3,517 differentially expressed genes (DEGs) were identified. KEGG enrichment analysis indicated that flavonoid pathway was overrepresented. Among the DAMs, the major components were flavonoids (104, 51.2%) followed by phenolic acids (30, 14.7%). Seven of top 10 flavonoid glycosides in HJH were highly accumulated and positively correlated with 10 glucosyltransferase genes. Collectively, higher content of flavonoid glycosides in HJH peels than in SHHJ peels might contribute to the distinct health-promoting effect, which provides a novel insight into improving the fruit quality of citrus as a health-promoting food resource.

Citrus reticulata 'Huajuhong' (HJH) 和C. reticulata'三湖红菊'（SHHJ）在果皮中含有不同水平的生物活性成分，包括黄酮类衍生物，但其潜在机制尚不清楚。代谢组和转录组的综合分析比较研究了 HJH 和 SHHJ 果皮的差异。HJH果皮中总黄酮含量显着高于SHHJ。鉴定了 203 种差异累积代谢物 (DAM) 和 3,517 种差异表达基因 (DEG)。KEGG 富集分析表明类黄酮途径过多。在 DAM 中，主要成分是类黄酮 (104, 51.2%)，其次是酚酸 (30, 14.7%)。HJH 中前 10 种黄酮苷中的 7 种高度积累并与 10 个葡萄糖基转移酶基因呈正相关。总的来说，